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Burden of multidrug-resistant bacteria among HIV-positive individuals in Ethiopia: A systematic review and meta-analysis

Author

Listed:
  • Muluneh Assefa
  • Azanaw Amare
  • Mitkie Tigabie
  • Getu Girmay
  • Abebaw Setegn
  • Yenesew Mihret Wondmagegn
  • Mebratu Tamir
  • Debaka Belete
  • Melak Aynalem
  • Teshome Belachew
  • Sirak Biset

Abstract

Background: Multidrug-resistant (MDR) bacteria are a significant cause of severe infections, particularly in human immunodeficiency virus (HIV)-positive individuals because of their weakened immunity. Since there was no previous pooled representative data regarding the MDR bacteria among HIV-positive individuals in Ethiopia, this systematic review and meta-analysis is required. Methods: This study was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A literature search was performed using PubMed, Medline, EMBASE, Google Scholar, Hinari, Web of Science, Science Direct, and African Journals Online databases. Data were extracted using Microsoft Excel 2019 and analyzed using STATA version 11.0 software. A random-effects model was used to estimate the pooled effect size of outcome variables across studies with a 95% confidence interval. The I2 statistic was used to check for heterogeneity. The presence of publication bias was determined using a funnel plot and Egger’s test with a p-value

Suggested Citation

  • Muluneh Assefa & Azanaw Amare & Mitkie Tigabie & Getu Girmay & Abebaw Setegn & Yenesew Mihret Wondmagegn & Mebratu Tamir & Debaka Belete & Melak Aynalem & Teshome Belachew & Sirak Biset, 2024. "Burden of multidrug-resistant bacteria among HIV-positive individuals in Ethiopia: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 19(8), pages 1-17, August.
    • Handle: RePEc:plo:pone00:0309418
    DOI: 10.1371/journal.pone.0309418
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