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Efficacy and safety of berberine plus 5-ASA for ulcerative colitis: A systematic review and meta-analysis

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  • Jilei Li
  • Chenchen Zhang
  • Yanchao Xu
  • Lili Yang

Abstract

Purpose: This study aimed to assess the efficacy and safety of berberine(BBR) plus 5-aminosalicylic acid (5-ASA) for treating ulcerative colitis (UC). Methods: A comprehensive search was conducted in electronic databases, including Medline/PubMed, Sinomed, Embase, CNKI, Wanfang, and VIP, through January 2024 to identify all randomized controlled trials (RCTs) that administered BBR conjunction in standard therapy(5-ASA) for to support the treatment of UC. The data were synthesized using a meta-analysis approach with RevMan 5.4.1. The primary endpoint was the clinical efficacy rate. In contrast, the secondary endpoints included the Baron score, disease activity index (DAI) score, symptom relief latency, inflammatory markers, immunological indicators, and adverse events. Results: In this analysis, 10 RCTs comprising 952 patients with UC were examined. BBR considerably improved the clinical efficacy rate (RR = 1.22, 95% CI [1.15, 1.30], P 0.05). Conclusion: BBR demonstrates substantial efficacy in treating UC without causing severe adverse reactions and may serve as a viable complementary therapy. However, its clinical application warrants confirmation by additional high-quality, low-bias RCTs.

Suggested Citation

  • Jilei Li & Chenchen Zhang & Yanchao Xu & Lili Yang, 2024. "Efficacy and safety of berberine plus 5-ASA for ulcerative colitis: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 19(9), pages 1-16, September.
    • Handle: RePEc:plo:pone00:0309144
    DOI: 10.1371/journal.pone.0309144
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