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A causal relationship between sarcopenia and cognitive impairment: A Mendelian randomization study

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  • Hengzhi Liu
  • Yi Fan
  • Jie Liang
  • Aixin Hu
  • Wutong Chen
  • Hua Wang
  • Yifeng Fan
  • Mingwu Li
  • Jun Duan
  • Qinzhi Wang

Abstract

Objective: Sarcopenia and cognitive impairment often coexist in the elderly. In this study, we investigated the causal relationship between sarcopenia-related muscle characteristics and cognitive performance. Methods: We used linkage disequilibrium score regression (LDSC) and Mendelian Randomization (MR) analyses to estimate genetic correlations and causal relationships between genetically predicted sarcopenia-related muscle traits and cognitive function, as well as cognitive function-based discovery samples and replicated samples. Estimated effect sizes were derived from a fixed-effects meta-analysis. Results: Our univariate genome-wide association study (GWAS) meta-analysis indicated a causal relationship between appendicular lean mass (ALM) (β = 0.049; 95% confidence interval (CI): 0.032–0.066, P

Suggested Citation

  • Hengzhi Liu & Yi Fan & Jie Liang & Aixin Hu & Wutong Chen & Hua Wang & Yifeng Fan & Mingwu Li & Jun Duan & Qinzhi Wang, 2024. "A causal relationship between sarcopenia and cognitive impairment: A Mendelian randomization study," PLOS ONE, Public Library of Science, vol. 19(9), pages 1-11, September.
    • Handle: RePEc:plo:pone00:0309124
    DOI: 10.1371/journal.pone.0309124
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