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Effects of aerobic, resistance and combined training on endothelial function and arterial stiffness in older adults: A systematic review and meta-analysis

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  • Raphael Silveira Nunes da Silva
  • Diego Silveira da Silva
  • Patrícia Caetano de Oliveira
  • Gustavo Waclawovsky
  • Maximiliano Isoppo Schaun

Abstract

We conducted a systematic review of randomized clinical trials evaluating the effects of aerobic, resistance and/or combined training on flow-mediated dilation (FMD) and/or pulse wave velocity (PWV) in older adults. The studies were selected from the electronic databases PubMed, Cochrane, LILACS, EMBASE, Web of Science, and the gray literature. We assessed the studies using Cochrane risk of bias (RoB2) tool and the GRADE tool. The GRADE assessment showed moderate quality of evidence for aerobic training and resistance training and very low for combined training. The measures of effects are presented as mean differences of the intervention group versus the control group and related 95% confidence intervals (95% CIs) pooled by a random-effects model using an inverse variance method. Our analysis of 24 RCTs (Intervention group [n = 251]: 67.7 ± 5.6 years old; control group [n = 228]: 68.7 ± 5.9 years old) showed that aerobic training was effective to improve FMD (0.64% [95% CI 0.24 to 1.03], p = 0.002) and PWV (–1.21 m/s [95% CI –1.37 to –1.05], p

Suggested Citation

  • Raphael Silveira Nunes da Silva & Diego Silveira da Silva & Patrícia Caetano de Oliveira & Gustavo Waclawovsky & Maximiliano Isoppo Schaun, 2024. "Effects of aerobic, resistance and combined training on endothelial function and arterial stiffness in older adults: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 19(12), pages 1-23, December.
    • Handle: RePEc:plo:pone00:0308600
    DOI: 10.1371/journal.pone.0308600
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