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Three months use of Hybrid Closed Loop Systems improves glycated hemoglobin levels in adolescents and children with type 1 diabetes: A meta-analysis

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  • Yuan-yuan WANG
  • Hui-min YING
  • Fang TIAN
  • Xiao-lu QIAN
  • Zhen-feng Zhou

Abstract

Background: Longer outpatient studies have demonstrated that hybrid closed loop (HCL) use has led to a concomitant reduction in glycated hemoglobin(HbA1c) by 0.3%–0.7%. However, reports have also indicated that HbA1c levels are not declined in the long-term use of HCL. Therefore, we wonder that 3 months use of HCL could improve glycated hemoglobin levels in adolescents and children with T1D. Methods: Relevant studies were searched electronically in the Cochrane Library, PubMed, and Embase utilizing the key words “Pediatrics or Child or Adolescent”, “Insulin Infusion Systems” and “Diabetes Mellitus” from inception to 17th March 2024 to evaluate the performance of HCL on HbA1c in adolescents, and children with T1D. Results: Nine studies involving 927 patients were identified. Three months use of HCL show a beneficial effect on HbA1c management (p 0.05). The overall percentage of hyperglycemic time was significantly decreased in HCL group compared to the control group when it was defined as >180 mg/dL (p 250 mg/dL (p = 0.007, I2 = 86%) and >300 mg/dL (p = 0.005; I2 = 76%). The mean glucose level was significantly decreased by HCL (p

Suggested Citation

  • Yuan-yuan WANG & Hui-min YING & Fang TIAN & Xiao-lu QIAN & Zhen-feng Zhou, 2024. "Three months use of Hybrid Closed Loop Systems improves glycated hemoglobin levels in adolescents and children with type 1 diabetes: A meta-analysis," PLOS ONE, Public Library of Science, vol. 19(8), pages 1-14, August.
    • Handle: RePEc:plo:pone00:0308202
    DOI: 10.1371/journal.pone.0308202
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