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Prognostic value of baseline alkaline phosphatase of 177Lu‐PSMA radioligand therapy in metastatic castration‐resistant prostate cancer: A systematic review and meta‐analysis

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  • Tianhe Zhang
  • Wuxue Li
  • Haiyang Wei
  • Zhiheng Huang
  • Junkai Yang
  • Hanyi Zeng
  • Zhiyong Zhou
  • Xinghua Zhao

Abstract

Background: Current studies have shown inconsistent results regarding the impact of baseline alkaline phosphatase (ALP) levels on the prognosis of metastatic castration-resistant prostate cancer (mCRPC) patients who undergo 177Lu-prostate-specific membrane antigen (PSMA) radioligand therapy (PRLT). Therefore, a comprehensive meta-analysis is needed to clarify the implications. Methods: This study was carried out in full compliance with the PRISMA protocol 2020, and a comprehensive search was conducted through PubMed, Web of Science, and Embase for published literature up to April 1st, 2024. Random-effects models were used to assess the correlation between baseline ALP and overall survival (OS) or progression-free survival (PFS) of mCRPC patients treated with 177Lu-PRLT, with a significance level set at α = 0.05. Results: A total of 12 articles were included in this study. The pooled effect estimates for baseline ALP and OS were 1.134 (95% CI: 1.035–1.245), I2 = 78.7%, P

Suggested Citation

  • Tianhe Zhang & Wuxue Li & Haiyang Wei & Zhiheng Huang & Junkai Yang & Hanyi Zeng & Zhiyong Zhou & Xinghua Zhao, 2024. "Prognostic value of baseline alkaline phosphatase of 177Lu‐PSMA radioligand therapy in metastatic castration‐resistant prostate cancer: A systematic review and meta‐analysis," PLOS ONE, Public Library of Science, vol. 19(12), pages 1-12, December.
    • Handle: RePEc:plo:pone00:0307826
    DOI: 10.1371/journal.pone.0307826
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