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Trends in hepatocellular carcinoma and viral hepatitis treatment in older Americans

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  • Joy Jiang
  • Meredith S Shiels
  • Donna Rivera
  • Marc G Ghany
  • Eric A Engels
  • Thomas R O’Brien

Abstract

Background: Incidence of hepatocellular carcinoma (HCC) had been increasing steadily among older Americans but plateaued in 2015–2017. Chronic infection with hepatitis B virus (HBV) or hepatitis C virus (HCV) are important causes of HCC. The impact of improved treatments for these infections on recent trends in HCC incidence is unclear. Aims: To examine the relationship between use of antiviral therapy for chronic viral hepatis and HCC incidence in older Americans. Methods: We used 2007–2017 data from the Surveillance, Epidemiology, and End Results—Medicare database to estimate age-standardized incidence rates and average annual percent changes (AAPCs) for viral hepatitis-attributable HCC among individuals ≥66 years. We analyzed data from Medicare Part D to determine the frequency of HBV and HCV treatment utilization in this population. Results: Overall HCC incidence increased 10.5%, from 22.2/100,000 in 2007 to 24.5/100,000 in 2017 (AAPC, 1.3%). During that time, HBV-attributable HCC rates decreased from 2.5 to 2.0/100,000 (AAPC, -1.6%), while HCV-attributable HCC rose from 6.6 to 8.0/100,000 (AAPC, 2.0%). HBV treatment among patients with HBV infection increased by 66% (2007, 7.4%; 2015, 12.3%). Treatment for HCV was stable at

Suggested Citation

  • Joy Jiang & Meredith S Shiels & Donna Rivera & Marc G Ghany & Eric A Engels & Thomas R O’Brien, 2024. "Trends in hepatocellular carcinoma and viral hepatitis treatment in older Americans," PLOS ONE, Public Library of Science, vol. 19(11), pages 1-13, November.
    • Handle: RePEc:plo:pone00:0307746
    DOI: 10.1371/journal.pone.0307746
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