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Zinc and thyroid cancer: A systematic review and meta-analysis protocol

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Listed:
  • Aline Alves Soares
  • Yasmin Guerreiro Nagashima
  • Camila Xavier Alves
  • Kleyton Santos de Medeiros
  • Márcia Marília Gomes Dantas Lopes
  • José Brandão-Neto

Abstract

Introduction: The thyroid cancer has the ninth larger incidence of cancer in the world. Investigations related to the exposure to metals have become important due to the sensibility of the thyroid gland to them. Studies reveal that carcinogenic progressions are associated to the deficiency of the essential trace elements. In this context, the zinc is highlighted, essential for the metabolism of the thyroidal hormone and has a potential relation with the pathogenesis of the thyroid cancer. The objective of this systematic review and meta-analysis is to evaluate the low serum zinc as a risk factor for thyroid cancer in adults. Methods and analysis: PubMed/MEDLINE, Scopus, Embase and LILACS databases will be searched for observational studies investigating the low serum zinc as a risk factor for thyroid cancer in adults. No language or publication period restrictions will be imposed. The primary outcome will be that the low serum zinc is a risk factor for thyroid cancer. Three independent reviewers will select the studies and extract data from the original publications. The risk-of-bias will be assessed by using the Newcastle-Ottawa Quality Assessment Scale (NOS). Data synthesis will be performed using the R software (V.4.3.1) and to assess heterogeneity, we will compute the I2 statistic and the results will be based on either random-effects or fixed-effects models, depending on the heterogeneity. The Grading of Recommendations, Development, and Evaluation (GRADE) system will be used to evaluate the reliability and quality of evidence. Prospero registration number: International Prospective Register of Systematic Reviews (PROSPERO) CRD42023463747.

Suggested Citation

  • Aline Alves Soares & Yasmin Guerreiro Nagashima & Camila Xavier Alves & Kleyton Santos de Medeiros & Márcia Marília Gomes Dantas Lopes & José Brandão-Neto, 2024. "Zinc and thyroid cancer: A systematic review and meta-analysis protocol," PLOS ONE, Public Library of Science, vol. 19(8), pages 1-9, August.
    • Handle: RePEc:plo:pone00:0307617
    DOI: 10.1371/journal.pone.0307617
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    References listed on IDEAS

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    1. Immacolata Cristina Nettore & Annamaria Colao & Paolo Emidio Macchia, 2018. "Nutritional and Environmental Factors in Thyroid Carcinogenesis," IJERPH, MDPI, vol. 15(8), pages 1-11, August.
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