IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0306983.html

Genome-wide association studies on periodontitis: A systematic review

Author

Listed:
  • Chenyi Gao
  • Mark Iles
  • Harriet Larvin
  • David Timothy Bishop
  • David Bunce
  • Mark Ide
  • Fanyiwen Sun
  • Susan Pavitt
  • Jianhua Wu
  • Jing Kang

Abstract

Objectives: This study aims to systematically review the existing literature and critically appraise the evidence of genome-wide association studies (GWAS) on periodontitis. This study also aims to synthesise the findings of genetic risk variants of periodontitis from included GWAS. Methods: A systematic search was conducted on PubMed, GWAS Catalog, MEDLINE, GLOBAL HEALTH and EMBASE via Ovid for GWAS on periodontitis. Only studies exploring single-nucleotide polymorphisms(SNPs) associated with periodontitis were eligible for inclusion. The quality of the GWAS was assessed using the Q-genie tool. Information such as study population, ethnicity, genomic data source, phenotypic characteristics(definition of periodontitis), and GWAS methods(quality control, analysis stages) were extracted. SNPs that reached conventional or suggestive GWAS significance level(5e-8 or 5e-06) were extracted and synthesized. Results: A total of 15 good-quality GWAS on periodontitis were included (Q-genie scores ranged from 38–50). There were huge heterogeneities among studies. There were 11 identified risk SNPs (rs242016, rs242014, rs10491972, rs242002, rs2978951, rs2738058, rs4284742, rs729876, rs149133391, rs1537415, rs12461706) at conventional GWAS significant level (p

Suggested Citation

  • Chenyi Gao & Mark Iles & Harriet Larvin & David Timothy Bishop & David Bunce & Mark Ide & Fanyiwen Sun & Susan Pavitt & Jianhua Wu & Jing Kang, 2024. "Genome-wide association studies on periodontitis: A systematic review," PLOS ONE, Public Library of Science, vol. 19(9), pages 1-23, September.
    • Handle: RePEc:plo:pone00:0306983
    DOI: 10.1371/journal.pone.0306983
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0306983
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0306983&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0306983?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0306983. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.