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The relationship between mechanical power normalized to dynamic lung compliance and weaning outcomes in mechanically ventilated patients

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  • Yao Yan
  • Zhiqiang Du
  • Haoran Chen
  • Suxia Liu
  • Xiaobing Chen
  • Xiaomin Li
  • Yongpeng Xie

Abstract

Background: Prolonged mechanical ventilation is associated with an increased risk of mortality in these patients. However, there exists a significant clinical need for novel indicators that can complement traditional weaning evaluation methods and effectively guide ventilator weaning. Objectives: To investigate the specific relationship between mechanical power normalized to dynamic lung compliance (Cdyn-MP) and weaning outcomes in patients on mechanical ventilation for more than 24 hours, as well as those who underwent a T-tube weaning strategy. Methods: A retrospective cohort study was conducted using the Medical Information Mart for Intensive Care-IV v1.0 database (MIMIC-IV v1.0). Patients who received invasive mechanical ventilation for more than 24 hours and underwent a T-tube ventilation strategy for weaning were enrolled. Patients were divided into two groups based on their weaning outcome: weaning success and failure. Ventilation parameter data were collected every 4 hours during the first 24 hours before the first spontaneous breathing trial (SBT). Results: Of all the 3,695 patients, 1,421 (38.5%) experienced weaning failure. Univariate logistic regression analysis revealed that the risk of weaning failure increased as the Cdyn-MP level rose (OR 1.34, 95% CI 1.31–1.38, P

Suggested Citation

  • Yao Yan & Zhiqiang Du & Haoran Chen & Suxia Liu & Xiaobing Chen & Xiaomin Li & Yongpeng Xie, 2024. "The relationship between mechanical power normalized to dynamic lung compliance and weaning outcomes in mechanically ventilated patients," PLOS ONE, Public Library of Science, vol. 19(8), pages 1-14, August.
    • Handle: RePEc:plo:pone00:0306116
    DOI: 10.1371/journal.pone.0306116
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