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Pharmaceutical cost dynamics for the treatment of rifampicin-resistant tuberculosis in children and adolescents in South Africa, India, and the Philippines

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Listed:
  • Thomas Wilkinson
  • Anthony J Garcia-Prats
  • Tina Sachs
  • Mandar Paradkar
  • Nishi Suryavanshi
  • Aarti Kinikar
  • Melchor V Frias
  • Edina Sinanovic
  • Anneke C Hesseling
  • James A Seddon
  • Megan Palmer

Abstract

Rifampicin-resistant (RR) tuberculosis (TB) in children is a major global health concern but is often neglected in economics research. Accurate cost estimations across the spectrum of paediatric RR-TB treatment regimens are critical inputs for prioritisation and budgeting decisions, and an existing knowledge gap at local and international levels. This normative cost analysis was nested in a Phase I/II pharmacokinetics, safety, tolerability, and acceptability trial of TB medications in children in South Africa, the Philippines and India. It assessed the pharmaceutical costs of 36 childhood RR-TB regimens using combinations from 16 different medicines in 34 oral formulations (adult and child-friendly) in 11 weight bands in children

Suggested Citation

  • Thomas Wilkinson & Anthony J Garcia-Prats & Tina Sachs & Mandar Paradkar & Nishi Suryavanshi & Aarti Kinikar & Melchor V Frias & Edina Sinanovic & Anneke C Hesseling & James A Seddon & Megan Palmer, 2024. "Pharmaceutical cost dynamics for the treatment of rifampicin-resistant tuberculosis in children and adolescents in South Africa, India, and the Philippines," PLOS ONE, Public Library of Science, vol. 19(7), pages 1-16, July.
    • Handle: RePEc:plo:pone00:0305930
    DOI: 10.1371/journal.pone.0305930
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