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Combination of sarcopenia and systemic inflammation-based markers for predicting the prognosis of patients undergoing pancreaticoduodenectomy for pancreatic cancer

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  • Masashi Utsumi
  • Masaru Inagaki
  • Koji Kitada
  • Naoyuki Tokunaga
  • Kosuke Yunoki
  • Hiroki Okabayashi
  • Ryosuke Hamano
  • Hideaki Miyasou
  • Yousuke Tsunemitsu
  • Shinya Otsuka

Abstract

Background: This study aimed to evaluate the effects of sarcopenia and inflammation on the prognosis of patients with pancreatic cancer after pancreaticoduodenectomy. Methods: Eighty patients who had undergone pancreaticoduodenectomy for pancreatic cancer between July 2010 and December 2023 were included in this study. The psoas muscle index was used to assess sarcopenia. The C-reactive protein-to-albumin ratio, prognostic nutritional index, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio were used to calculate the preoperative inflammatory marker levels. The prognostic factors for overall survival were determined using Cox regression analysis. Results: Twenty-four patients were diagnosed with sarcopenia. Sarcopenia showed a significant association with advanced tumor stage. Univariate analysis revealed a significant reduction in overall survival in patients with a prognostic nutritional index of

Suggested Citation

  • Masashi Utsumi & Masaru Inagaki & Koji Kitada & Naoyuki Tokunaga & Kosuke Yunoki & Hiroki Okabayashi & Ryosuke Hamano & Hideaki Miyasou & Yousuke Tsunemitsu & Shinya Otsuka, 2024. "Combination of sarcopenia and systemic inflammation-based markers for predicting the prognosis of patients undergoing pancreaticoduodenectomy for pancreatic cancer," PLOS ONE, Public Library of Science, vol. 19(6), pages 1-17, June.
    • Handle: RePEc:plo:pone00:0305844
    DOI: 10.1371/journal.pone.0305844
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