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Reinterpretation of the results of randomized clinical trials

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  • Farrokh Habibzadeh

Abstract

Background: Randomized clinical trials (RCTs) shape our clinical practice. Several studies report a mediocre replicability rate of the studied RCTs. Many researchers believe that the relatively low replication rate of RCTs is attributed to the high p value significance threshold. To solve this problem, some researchers proposed using a lower threshold, which is inevitably associated with a decrease in the study power. Methods: The results of 22 500 RCTs retrieved from the Cochrane Database of Systematic Reviews (CDSR) were reinterpreted using 2 fixed p significance threshold (0.05 and 0.005), and a recently proposed flexible threshold that minimizes the weighted sum of errors in statistical inference. Results: With p

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  • Farrokh Habibzadeh, 2024. "Reinterpretation of the results of randomized clinical trials," PLOS ONE, Public Library of Science, vol. 19(6), pages 1-16, June.
    • Handle: RePEc:plo:pone00:0305575
    DOI: 10.1371/journal.pone.0305575
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