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Systematic review and meta-analysis: Evaluating the influence of intrahepatic cholestasis of pregnancy on obstetric and neonatal outcomes

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  • Xuexia Huang
  • Huifeng Gu
  • Pinghua Shen
  • Xiaoxing Zhang
  • Anping Fei

Abstract

Background: Intrahepatic cholestasis of pregnancy (ICP) is a serious liver conditions that negatively impacts obstetric and neonatal outcomes. Elevated levels of bile acid, particularly glycine conjugate, may compromise blood flow and cause functional hypoxia-ischemia. Aims: This meta-analysis aims to assess the association between ICP and key pregnancy outcomes including emergency caesarian sections (C-sections), preeclampsia, hemorrhage, preterm birth, small for gestational age, admission rate to neonatal intensive care union (NICU), gestational age, and stillbirth. Materials and methods: Literature search across five databases (PubMed, Embase, Web of Science) was done to detect relevant studies published up until June 2023. Meta-analysis of the identified studies was done using a random-effects model, and the results presented as Odds ratio (OR). Results: A literature search identified 662 studies. Of them, 21 met the inclusion criteria. There was a significant association between ICP and odds of C-section (OR: 1.42, p

Suggested Citation

  • Xuexia Huang & Huifeng Gu & Pinghua Shen & Xiaoxing Zhang & Anping Fei, 2024. "Systematic review and meta-analysis: Evaluating the influence of intrahepatic cholestasis of pregnancy on obstetric and neonatal outcomes," PLOS ONE, Public Library of Science, vol. 19(6), pages 1-14, June.
    • Handle: RePEc:plo:pone00:0304604
    DOI: 10.1371/journal.pone.0304604
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