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MiRNA encoded PTEN’s impact on clinical-pathological features and prognosis in osteosarcoma: A systematic review and meta-analysis

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  • Edward Kurnia Setiawan Limijadi
  • Robin Novriansyah
  • Danendra Rakha Putra Respati
  • Kevin Christian Tjandra

Abstract

Background: Osteosarcoma (OSC) is considered one of the most common malignant bone tumours in adolescents. Due to OSC’s poor prognosis, a comprehensive approach to exploring these aspects is highly needed to improve the survival probability of OSC. In this study, we tried to explore the significance of miRNA-encoded PTEN for clinical-pathological features and prognostic value in OSC. Method: We performed this systematic review and meta-analysis using articles and sources published between 2013 and 2023 from six databases (Scopus, PubMed, ProQuest, Science Direct, Sage Pub, and Cochrane). Included studies were clinical cross-sectional studies. Other study designs, articles not written in English, without full text, and not relevant—were excluded. Then, ROBINS-I is used to evaluate the distance. The results are constructed according to the PICOS criteria in a table. The expression of miRNA related to OSC is assessed in the meta-analysis as the main outcome to determine its ability as a diagnostic and prognostic agent for OSC. This systematic review followed the PRISMA guidelines. Results: A total of 17 studies were included in the final screening. The meta-analysis showed significantly increased (p

Suggested Citation

  • Edward Kurnia Setiawan Limijadi & Robin Novriansyah & Danendra Rakha Putra Respati & Kevin Christian Tjandra, 2024. "MiRNA encoded PTEN’s impact on clinical-pathological features and prognosis in osteosarcoma: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 19(9), pages 1-16, September.
    • Handle: RePEc:plo:pone00:0304543
    DOI: 10.1371/journal.pone.0304543
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