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Determinants of sputum culture conversion time in multidrug-resistant tuberculosis patients in ALERT comprehensive specialized hospital, Addis Ababa, Ethiopia: A retrospective cohort study

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Listed:
  • Muluye Abebe
  • Abay Atnafu
  • Melaku Tilahun
  • Nejmia Sero
  • Sebisib Neway
  • Mekdes Alemu
  • Getachew Tesfaye
  • Adane Mihret
  • Kidist Bobosha
  • Chengsong Wan

Abstract

Introduction: The treatment response of multi-drug resistance tuberculosis (MDR-Tuberculosis) patients is mainly dictated by the sputum culture conversion. An earlier culture conversion is a remarkable indicator of the improvement in the treatment response. In this study, we aimed to determine the time to culture conversion and its associated factors among MDR-Tuberculosis patients in All Africa Leprosy, Tuberculosis and Rehabilitation Training Center (ALERT) Hospital, Addis Ababa, Ethiopia. Methods: A retrospective cohort study was conducted on 120 MDR-Tuberculosis patients attending ALERT Hospital from 2018–2022. Kaplan-Meier methods were used to determine the time to initial sputum culture conversion. All relevant laboratory, socio-demographic characteristics, and other clinical data were collected by chart abstraction using a structure data extraction form. The log-rank test was used to determine the survival rate. To identify the predictors of culture conversion, bivariate and multivariate Cox proportional hazard regression analysis was used. The hazard ratio (HR) with a 95% confidence interval was used to estimate the effect of each variable on the initial culture conversion. A test with a P value of

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  • Muluye Abebe & Abay Atnafu & Melaku Tilahun & Nejmia Sero & Sebisib Neway & Mekdes Alemu & Getachew Tesfaye & Adane Mihret & Kidist Bobosha & Chengsong Wan, 2024. "Determinants of sputum culture conversion time in multidrug-resistant tuberculosis patients in ALERT comprehensive specialized hospital, Addis Ababa, Ethiopia: A retrospective cohort study," PLOS ONE, Public Library of Science, vol. 19(5), pages 1-12, May.
    • Handle: RePEc:plo:pone00:0304507
    DOI: 10.1371/journal.pone.0304507
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    1. Kefyalew Addis Alene & Kerri Viney & Hengzhong Yi & Emma S McBryde & Kunyun Yang & Liqiong Bai & Darren J Gray & Zuhui Xu & Archie C A Clements, 2018. "Comparison of the validity of smear and culture conversion as a prognostic marker of treatment outcome in patients with multidrug-resistant tuberculosis," PLOS ONE, Public Library of Science, vol. 13(5), pages 1-17, May.
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