IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0304115.html
   My bibliography  Save this article

Electroencephalogram synchronization measure as a predictive biomarker of Vagus nerve stimulation response in refractory epilepsy: A retrospective study

Author

Listed:
  • Venethia Danthine
  • Lise Cottin
  • Alexandre Berger
  • Enrique Ignacio Germany Morrison
  • Giulia Liberati
  • Susana Ferrao Santos
  • Jean Delbeke
  • Antoine Nonclercq
  • Riëm El Tahry

Abstract

There are currently no established biomarkers for predicting the therapeutic effectiveness of Vagus Nerve Stimulation (VNS). Given that neural desynchronization is a pivotal mechanism underlying VNS action, EEG synchronization measures could potentially serve as predictive biomarkers of VNS response. Notably, an increased brain synchronization in delta band has been observed during sleep–potentially due to an activation of thalamocortical circuitry, and interictal epileptiform discharges are more frequently observed during sleep. Therefore, investigation of EEG synchronization metrics during sleep could provide a valuable insight into the excitatory-inhibitory balance in a pro-epileptogenic state, that could be pathological in patients exhibiting a poor response to VNS. A 19-channel-standard EEG system was used to collect data from 38 individuals with Drug-Resistant Epilepsy (DRE) who were candidates for VNS implantation. An EEG synchronization metric–the Weighted Phase Lag Index (wPLI)—was extracted before VNS implantation and compared between sleep and wakefulness, and between responders (R) and non-responders (NR). In the delta band, a higher wPLI was found during wakefulness compared to sleep in NR only. However, in this band, no synchronization difference in any state was found between R and NR. During sleep and within the alpha band, a negative correlation was found between wPLI and the percentage of seizure reduction after VNS implantation. Overall, our results suggest that patients exhibiting a poor VNS efficacy may present a more pathological thalamocortical circuitry before VNS implantation. EEG synchronization measures could provide interesting insights into the prerequisites for responding to VNS, in order to avoid unnecessary implantations in patients showing a poor therapeutic efficacy.

Suggested Citation

  • Venethia Danthine & Lise Cottin & Alexandre Berger & Enrique Ignacio Germany Morrison & Giulia Liberati & Susana Ferrao Santos & Jean Delbeke & Antoine Nonclercq & Riëm El Tahry, 2024. "Electroencephalogram synchronization measure as a predictive biomarker of Vagus nerve stimulation response in refractory epilepsy: A retrospective study," PLOS ONE, Public Library of Science, vol. 19(6), pages 1-15, June.
    • Handle: RePEc:plo:pone00:0304115
    DOI: 10.1371/journal.pone.0304115
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0304115
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0304115&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0304115?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. S. M. Purcell & D. S. Manoach & C. Demanuele & B. E. Cade & S. Mariani & R. Cox & G. Panagiotaropoulou & R. Saxena & J. Q. Pan & J. W. Smoller & S. Redline & R. Stickgold, 2017. "Characterizing sleep spindles in 11,630 individuals from the National Sleep Research Resource," Nature Communications, Nature, vol. 8(1), pages 1-16, August.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Lainey E. Hunnicutt & Makenzie Corgan & Sarah R. Brown & Alyssa Nygaard & George Lesley Meares & Scott R. Collier, 2024. "Sleep Differences in Firefighters: Barracks vs. Home," IJERPH, MDPI, vol. 21(9), pages 1-8, August.
    2. Judith Nicolas & Bradley R. King & David Lévesque & Latifa Lazzouni & Gaëlle Leroux & David Wang & Nir Grossman & Stephan P. Swinnen & Julien Doyon & Julie Carrier & Geneviève Albouy, 2025. "Unraveling the neurophysiological correlates of phase-specific enhancement of motor memory consolidation via slow-wave closed-loop targeted memory reactivation," Nature Communications, Nature, vol. 16(1), pages 1-20, December.
    3. Xunda Wang & Alex T. L. Leong & Shawn Z. K. Tan & Eddie C. Wong & Yilong Liu & Lee-Wei Lim & Ed X. Wu, 2023. "Functional MRI reveals brain-wide actions of thalamically-initiated oscillatory activities on associative memory consolidation," Nature Communications, Nature, vol. 14(1), pages 1-21, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0304115. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.