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A machine learning approach for differentiating bipolar disorder type II and borderline personality disorder using electroencephalography and cognitive abnormalities

Author

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  • Mohammad-Javad Nazari
  • Mohammadreza Shalbafan
  • Negin Eissazade
  • Elham Khalilian
  • Zahra Vahabi
  • Neda Masjedi
  • Saeed Shiry Ghidary
  • Mozafar Saadat
  • Seyed-Ali Sadegh-Zadeh

Abstract

This study addresses the challenge of differentiating between bipolar disorder II (BD II) and borderline personality disorder (BPD), which is complicated by overlapping symptoms. To overcome this, a multimodal machine learning approach was employed, incorporating both electroencephalography (EEG) patterns and cognitive abnormalities for enhanced classification. Data were collected from 45 participants, including 20 with BD II and 25 with BPD. Analysis involved utilizing EEG signals and cognitive tests, specifically the Wisconsin Card Sorting Test and Integrated Cognitive Assessment. The k-nearest neighbors (KNN) algorithm achieved a balanced accuracy of 93%, with EEG features proving to be crucial, while cognitive features had a lesser impact. Despite the strengths, such as diverse model usage, it’s important to note limitations, including a small sample size and reliance on DSM diagnoses. The study suggests that future research should explore multimodal data integration and employ advanced techniques to improve classification accuracy and gain a better understanding of the neurobiological distinctions between BD II and BPD.

Suggested Citation

  • Mohammad-Javad Nazari & Mohammadreza Shalbafan & Negin Eissazade & Elham Khalilian & Zahra Vahabi & Neda Masjedi & Saeed Shiry Ghidary & Mozafar Saadat & Seyed-Ali Sadegh-Zadeh, 2024. "A machine learning approach for differentiating bipolar disorder type II and borderline personality disorder using electroencephalography and cognitive abnormalities," PLOS ONE, Public Library of Science, vol. 19(6), pages 1-15, June.
    • Handle: RePEc:plo:pone00:0303699
    DOI: 10.1371/journal.pone.0303699
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    References listed on IDEAS

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    1. Seyed-Ali Sadegh-Zadeh & Chandrasekhar Kambhampati, 2018. "Computational Investigation of Amyloid Peptide Channels in Alzheimer’s Disease," J, MDPI, vol. 2(1), pages 1-14, December.
    2. Tasci, Gulay & Gun, Mehmet Veysel & Keles, Tugce & Tasci, Burak & Barua, Prabal Datta & Tasci, Irem & Dogan, Sengul & Baygin, Mehmet & Palmer, Elizabeth Emma & Tuncer, Turker & Ooi, Chui Ping & Achary, 2023. "QLBP: Dynamic patterns-based feature extraction functions for automatic detection of mental health and cognitive conditions using EEG signals," Chaos, Solitons & Fractals, Elsevier, vol. 172(C).
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