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A META analysis and systematic review of the effects of exercise interventions on middle-aged and elderly patients with depression

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  • Zheng Zhang
  • Jia-Yun Liu
  • Kai-Tuo Zhu
  • Gui-Quan Huo

Abstract

Objective: This study sought to conduct a meticulous systematic review, delving into the efficacy of exercise interventions on depressive symptoms among middle-aged and older adults. Additionally, we aimed to scrutinize the nuanced influence of various intervention factors on the intricate relationship between exercise and depressive symptoms within this demographic. Methods: Our investigation involved an extensive search across multiple databases, including PubMed, Embase, Web of Science, and the Cochrane Library, spanning from the inception of these repositories to December 2023. Following a rigorous screening process, we identified and included 12 papers, encompassing a total of 994 subjects. Results: The meta-analysis unveiled a compelling overall effect size of exercise interventions on depressive symptoms in middle-aged and older individuals, represented by SMD = -0.41, with a 95% confidence interval of [-0.60, -0.22], and P

Suggested Citation

  • Zheng Zhang & Jia-Yun Liu & Kai-Tuo Zhu & Gui-Quan Huo, 2025. "A META analysis and systematic review of the effects of exercise interventions on middle-aged and elderly patients with depression," PLOS ONE, Public Library of Science, vol. 20(1), pages 1-23, January.
    • Handle: RePEc:plo:pone00:0303594
    DOI: 10.1371/journal.pone.0303594
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