IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0303343.html
   My bibliography  Save this article

Association between executive functions and COMT Val108/158Met polymorphism among healthy younger and older adults: A preliminary study

Author

Listed:
  • Zoltan Apa
  • Jessica Gilsoul
  • Vinciane Dideberg
  • Fabienne Collette

Abstract

Background and objectives: Genetic variability in the dopaminergic system could contribute to age-related impairments in executive control. In this study, we examined whether genetic polymorphism for catechol-O-methyltransferase (COMT Val158Met) is related to performance on updating, shifting and inhibition tasks. Methods: We administered a battery of executive tasks assessing updating, shifting and inhibition functions to 45 older and 55 younger healthy participants, and created composite z-scores associated to each function. Six groups were created based on genetic alleles (Val/Val, Val/Met, Met/Met) derived from the COMT gene and age (younger, older). Age and genotype effects were assessed with t-test and ANOVA (p

Suggested Citation

  • Zoltan Apa & Jessica Gilsoul & Vinciane Dideberg & Fabienne Collette, 2024. "Association between executive functions and COMT Val108/158Met polymorphism among healthy younger and older adults: A preliminary study," PLOS ONE, Public Library of Science, vol. 19(5), pages 1-19, May.
    • Handle: RePEc:plo:pone00:0303343
    DOI: 10.1371/journal.pone.0303343
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0303343
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0303343&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0303343?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Pilar Andrés & Martial Van der Linden, 2000. "Age-Related Differences in Supervisory Attentional System Functions," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 55(6), pages 373-380.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Stéphane Adam & Christelle Bay & Eric Bonsang & Sophie Germain & Sergio Perelman, 2006. "Occupational Activities and Cognitive Reserve: a Frontier Approach Applied to the Survey on Health, Ageing, and Retirement in Europe," CREPP Working Papers 0605, Centre de Recherche en Economie Publique et de la Population (CREPP) (Research Center on Public and Population Economics) HEC-Management School, University of Liège.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0303343. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.