IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0303261.html
   My bibliography  Save this article

A polygenic risk score for the QT interval is an independent predictor of drug-induced QT prolongation

Author

Listed:
  • Steven T Simon
  • Meng Lin
  • Katy E Trinkley
  • Ryan Aleong
  • Nicholas Rafaels
  • Kristy R Crooks
  • Michael J Reiter
  • Christopher R Gignoux
  • Michael A Rosenberg

Abstract

Drug-induced QT prolongation (diLQTS), and subsequent risk of torsade de pointes, is a major concern with use of many medications, including for non-cardiac conditions. The possibility that genetic risk, in the form of polygenic risk scores (PGS), could be integrated into prediction of risk of diLQTS has great potential, although it is unknown how genetic risk is related to clinical risk factors as might be applied in clinical decision-making. In this study, we examined the PGS for QT interval in 2500 subjects exposed to a known QT-prolonging drug on prolongation of the QT interval over 500ms on subsequent ECG using electronic health record data. We found that the normalized QT PGS was higher in cases than controls (0.212±0.954 vs. -0.0270±1.003, P = 0.0002), with an unadjusted odds ratio of 1.34 (95%CI 1.17–1.53, P

Suggested Citation

  • Steven T Simon & Meng Lin & Katy E Trinkley & Ryan Aleong & Nicholas Rafaels & Kristy R Crooks & Michael J Reiter & Christopher R Gignoux & Michael A Rosenberg, 2024. "A polygenic risk score for the QT interval is an independent predictor of drug-induced QT prolongation," PLOS ONE, Public Library of Science, vol. 19(6), pages 1-15, June.
    • Handle: RePEc:plo:pone00:0303261
    DOI: 10.1371/journal.pone.0303261
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0303261
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0303261&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0303261?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Antoine Poncet & Baris Gencer & Marc Blondon & Marianne Gex-Fabry & Christophe Combescure & Dipen Shah & Peter J Schwartz & Marie Besson & François R Girardin, 2015. "Electrocardiographic Screening for Prolonged QT Interval to Reduce Sudden Cardiac Death in Psychiatric Patients: A Cost-Effectiveness Analysis," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-14, June.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Christopher J. Cadham & Marie Knoll & Luz María Sánchez-Romero & K. Michael Cummings & Clifford E. Douglas & Alex Liber & David Mendez & Rafael Meza & Ritesh Mistry & Aylin Sertkaya & Nargiz Travis , 2022. "The Use of Expert Elicitation among Computational Modeling Studies in Health Research: A Systematic Review," Medical Decision Making, , vol. 42(5), pages 684-703, July.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0303261. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.