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Efficacy and safety of herbal medicine combined with acupuncture in pediatric epilepsy treatment: A meta-analysis of randomized controlled trials

Author

Listed:
  • Hong-Wen Su
  • Hsiao-Tien Chen
  • Chia-Li Kao
  • Kuo-Chuan Hung
  • Yao-Tsung Lin
  • Ping-Hsin Liu
  • Chien-Ming Lin
  • I-Wen Chen

Abstract

Objective: To evaluate the efficacy and safety of herbal medicine and acupuncture combination for pediatric epilepsy treatment. Methods: Databases were searched from their interception until October 2023 to identify randomized controlled trials focusing on the therapeutic efficacy of herbal medicine-acupuncture combination (intervention group) for pediatric epilepsy. The primary outcome was the risk of treatment failure, whereas the secondary outcomes included the risk of post-treatment electroencephalogram (EEG) abnormalities and adverse events. Subgroup analyses were conducted based on the type of herbal compound formulas. Meta-regression analysis was conducted to examine the influence of patient demographics and clinical history on the therapeutic efficacy of herbal medicine-acupuncture combination for pediatric epilepsy. To assess the cumulative evidence, trial sequential analysis (TSA) was performed. Results: The analysis included 10 trials involving a total of 882 pediatric patients. Meta-analysis revealed that the intervention group had a lower risk of treatment failure than the control group (risk ratio [RR] = 0.3, 95% confidence interval [CI]: 0.19–0.47, P

Suggested Citation

  • Hong-Wen Su & Hsiao-Tien Chen & Chia-Li Kao & Kuo-Chuan Hung & Yao-Tsung Lin & Ping-Hsin Liu & Chien-Ming Lin & I-Wen Chen, 2024. "Efficacy and safety of herbal medicine combined with acupuncture in pediatric epilepsy treatment: A meta-analysis of randomized controlled trials," PLOS ONE, Public Library of Science, vol. 19(5), pages 1-20, May.
    • Handle: RePEc:plo:pone00:0303201
    DOI: 10.1371/journal.pone.0303201
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