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Frailty and transplant-free survival of patients with liver cirrhosis: A meta-analysis

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  • Chunhui Yuan
  • Weihua Li
  • Jie Liu
  • Jianguo Li

Abstract

Background: Frailty is a common condition among patients with liver cirrhosis. Nonetheless, its role in predicting liver transplant-free survival (TFS) remains unclear. Aim: This systematic review and meta-analysis were conducted to elucidate the relationship between frailty and TFS in patients with cirrhosis. Methods: Cohort studies addressing the objective of this meta-analysis were extracted from PubMed, Embase, and Web of Science databases. Between-study heterogeneity was assessed with the Cochrane Q test, and the I^2 statistic was estimated. Random-effect models, considering potential heterogeneity, were employed to combine the results. Results: The meta-analysis encompassed 17 cohort studies involving 6273 patients with cirrhosis, of whom 1983 (31.6%) were classified as frail at baseline. The follow-up periods in the included studies ranged from 3 to 29 months, with an average duration of 11.5 months. The analysis revealed that frailty was significantly associated with a poor TFS (risk ratio [RR]: 2.07, 95% confidence interval: 1.72 to 2.50, p

Suggested Citation

  • Chunhui Yuan & Weihua Li & Jie Liu & Jianguo Li, 2024. "Frailty and transplant-free survival of patients with liver cirrhosis: A meta-analysis," PLOS ONE, Public Library of Science, vol. 19(5), pages 1-15, May.
    • Handle: RePEc:plo:pone00:0302836
    DOI: 10.1371/journal.pone.0302836
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