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Socioeconomic status and health disparities drive differences in accelerometer-derived physical activity in fatty liver disease and significant fibrosis

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  • Lucia Tabacu
  • Sajag Swami
  • Mark Ledbetter
  • Mohamad S Siddiqui
  • Ekaterina Smirnova

Abstract

Background and aims: The cornerstone of clinical management of patients with nonalcoholic fatty liver disease (NAFLD) are lifestyle changes such as increasing physical activity (PA) aimed at improving cardiometabolic risk. To inform NAFLD prevention and treatment guidelines we aimed to: (i) quantify the role of PA on lowering the risk for NAFLD and fibrosis; (ii) characterize NAFLD and fibrosis association with PA in the context of socioeconomic environment. Methods: A sample of 2648 participants from the NHANES 2003–2006 was selected to develop survey weighted multivariable logistic regression models for predicting NAFLD and significant fibrosis, diagnosed non-invasively via fatty liver index (FLI) and fibrosis-4 (FIB-4) index. The PA measures were obtained from a hip-worn accelerometer. Results: The predictive model for NAFLD showed AUC of 0.687 and a decrease of 43% in NAFLD risk with moderate vigorous PA (MVPA) (OR = 0.569, p

Suggested Citation

  • Lucia Tabacu & Sajag Swami & Mark Ledbetter & Mohamad S Siddiqui & Ekaterina Smirnova, 2024. "Socioeconomic status and health disparities drive differences in accelerometer-derived physical activity in fatty liver disease and significant fibrosis," PLOS ONE, Public Library of Science, vol. 19(5), pages 1-15, May.
    • Handle: RePEc:plo:pone00:0301774
    DOI: 10.1371/journal.pone.0301774
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    References listed on IDEAS

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    1. Jae Ho Park & Nam-Kyoo Lim & Hyun-Young Park, 2022. "Protective Effect of Leisure-Time Physical Activity and Resistance Training on Nonalcoholic Fatty Liver Disease: A Nationwide Cross-Sectional Study," IJERPH, MDPI, vol. 19(4), pages 1-11, February.
    2. Andrew Leroux & Junrui Di & Ekaterina Smirnova & Elizabeth J Mcguffey & Quy Cao & Elham Bayatmokhtari & Lucia Tabacu & Vadim Zipunnikov & Jacek K Urbanek & Ciprian Crainiceanu, 2019. "Organizing and Analyzing the Activity Data in NHANES," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 11(2), pages 262-287, July.
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