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Effect of spironolactone on survival in patients undergoing maintenance hemodialysis

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  • Seok Hui Kang
  • Bo Yeon Kim
  • Eun Jung Son
  • Gui Ok Kim
  • Jun Young Do

Abstract

Background: Previous studies have reported inconsistent results regarding the advantages or disadvantages of spironolactone use in patients undergoing hemodialysis (HD). This study aimed to evaluate survival according to the use of spironolactone in a large sample of patients undergoing maintenance HD. Methods: This retrospective study used laboratory and clinical data from the national HD Quality Assessment Program and claims data. The participants of the quality assessment program were patients who had been undergoing maintenance HD for ≥ 3 months, patients undergoing HD at least twice a week. Patients with no spironolactone prescription during the assessment periods were designated as the control group. Patients with one or more prescriptions of spironolactone during the assessment periods were assigned to the SPR group. Results: The number of patients in the control and SPR groups were 54,588 and 315, respectively. The 5-year survival rates were 69.1% and 59.1% in the control and SPR groups, respectively (P

Suggested Citation

  • Seok Hui Kang & Bo Yeon Kim & Eun Jung Son & Gui Ok Kim & Jun Young Do, 2024. "Effect of spironolactone on survival in patients undergoing maintenance hemodialysis," PLOS ONE, Public Library of Science, vol. 19(3), pages 1-10, March.
    • Handle: RePEc:plo:pone00:0301458
    DOI: 10.1371/journal.pone.0301458
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