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7T MP2RAGE for cortical myelin segmentation: Impact of aging

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  • Susanne G Mueller

Abstract

Background: Myelin and iron are major contributors to the cortical MR signal. The aim of this study was to investigate 1. Can MP2RAGE-derived contrasts at 7T in combination with k-means clustering be used to distinguish between heavily and sparsely myelinated layers in cortical gray matter (GM)? 2. Does this approach provide meaningful biological information? Methods: The following contrasts were generated from the 7T MP2RAGE images from 45 healthy controls (age: 19–75, f/m = 23/22) from the ATAG data repository: 1. T1 weighted image (UNI). 2. T1 relaxation image (T1map). 3. INVC/T1map ratio (RATIO). K-means clustering identified 6 clusters/tissue maps (csf, csf/gm-transition, wm, wm/gm transition, heavily myelinated cortical GM (dGM), sparsely myelinated cortical GM (sGM)). These tissue maps were then processed with SPM/DARTEL (volume-based analyses) and Freesurfer (surface-based analyses) and dGM and sGM volume/thickness of young adults (n = 27, 19–27 years) compared to those of older adults (n = 18, 42–75 years) at p

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  • Susanne G Mueller, 2024. "7T MP2RAGE for cortical myelin segmentation: Impact of aging," PLOS ONE, Public Library of Science, vol. 19(4), pages 1-18, April.
    • Handle: RePEc:plo:pone00:0299670
    DOI: 10.1371/journal.pone.0299670
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