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Crystal scatter effects in a large-area dual-panel Positron Emission Mammography system

Author

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  • Rahal Saaidi
  • Mercedes Rodríguez-Villafuerte
  • Héctor Alva-Sánchez
  • Arnulfo Martínez-Dávalos

Abstract

Positron Emission Mammography (PEM) is a valuable molecular imaging technique for breast studies using pharmaceuticals labeled with positron emitters and dual-panel detectors. PEM scanners normally use large scintillation crystals coupled to sensitive photodetectors. Multiple interactions of the 511 keV annihilation photons in the crystals can result in event mispositioning leading to a negative impact in radiopharmaceutical uptake quantification. In this work, we report the study of crystal scatter effects of a large-area dual-panel PEM system designed with either monolithic or pixelated lutetium yttrium orthosilicate (LYSO) crystals using the Monte Carlo simulation platform GATE. The results show that only a relatively small fraction of coincidences (~20%) arise from events where both coincidence photons undergo single interactions (mostly through photoelectric absorption) in the crystals. Most of the coincidences are events where at least one of the annihilation photons undergoes a chain of Compton scatterings: approximately 79% end up in photoelectric absorption while the rest (

Suggested Citation

  • Rahal Saaidi & Mercedes Rodríguez-Villafuerte & Héctor Alva-Sánchez & Arnulfo Martínez-Dávalos, 2024. "Crystal scatter effects in a large-area dual-panel Positron Emission Mammography system," PLOS ONE, Public Library of Science, vol. 19(3), pages 1-19, March.
    • Handle: RePEc:plo:pone00:0297829
    DOI: 10.1371/journal.pone.0297829
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