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Impact of the gene polymorphisms in the renin-angiotensin system on cardiomyopathy risk: A meta-analysis

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  • Xiaoxiao Jia
  • Liping Meng
  • Weiliang Tang
  • Liping Sun
  • Fang Peng
  • Peng Zhang

Abstract

Due to the inconsistent findings from various studies, the role of gene polymorphisms in the renin-angiotensin system in influencing the development of cardiomyopathy remains unclear. In this study, we conducted a systematic review and meta-analysis to summarize the findings regarding the impact of angiotensin converting enzyme (ACE) I/D, angiotensinogen (AGT) M235T, and angiotensin II Type 1 receptor (AGTR1) A1166C gene polymorphisms in patients with cardiomyopathy. We performed a comprehensive search of several electronic databases, including PubMed, Embase, the Cochrane Library, and Web of Science, covering articles published from the time of database creation to April 17, 2023. Studies on the assessment of genetic polymorphisms in genes related to the renin-angiotensin system in relation to cardiomyopathy were included. The primary outcome was cardiomyopathy. Risk of bias was assessed using the Newcastle-Ottawa Scale scale. The meta-analysis includes 19 studies with 4,052 cases and 5,592 controls. The ACE I/D polymorphisms were found to be associated with cardiomyopathy (allelic model D vs I: OR = 1.29, 95CI% = 1.08–1.52; dominant model DD+ID vs II: OR = 1.43, 95CI% = 1.01–2.02; recessive model DD vs ID+II: OR = 0.79, 95CI% = 0.64–0.98). AGT M235T polymorphism and cardiomyopathy were not significantly correlated (allelic model T vs M: OR = 1.26, 95CI% = 0.96–1.66; dominant model TT+MT vs MM: OR = 1.30, 95CI% = 0.98–1.73; recessive model TT vs MT+MM: OR = 0.63, 95CI% = 0.37–1.07). AGTR1 polymorphism and cardiomyopathy were not significantly associated under allelic model A vs C (OR = 0.69, 95CI% = 0.46–1.03) and recessive model AA vs CA+CC (OR = 0.89, 95CI% = 0.34–2.30), but under the dominant model AA+CA vs CC (OR = 0.51, 95CI% = 0.38–0.68). The current meta-analysis reveals that polymorphisms in ACE I/D may be a genetic risk factor for cardiomyopathy. There is an association between AGTR1 gene polymorphisms and risk of cardiomyopathy under the specific model.

Suggested Citation

  • Xiaoxiao Jia & Liping Meng & Weiliang Tang & Liping Sun & Fang Peng & Peng Zhang, 2024. "Impact of the gene polymorphisms in the renin-angiotensin system on cardiomyopathy risk: A meta-analysis," PLOS ONE, Public Library of Science, vol. 19(1), pages 1-17, January.
    • Handle: RePEc:plo:pone00:0295626
    DOI: 10.1371/journal.pone.0295626
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    References listed on IDEAS

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    1. Rong Luo & Xiaoping Li & Yuequn Wang & Yongqing Li & Yun Deng & Yongqi Wan & Zhigang Jiang & Wei Hua & Xiushan Wu, 2013. "The Influence of Angiotensin Converting Enzyme and Angiotensinogen Gene Polymorphisms on Hypertrophic Cardiomyopathy," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-9, October.
    2. Jianmin Yang & Yunhan Zhao & Panpan Hao & Xiao Meng & Mei Dong & Ying Wang & Yun Zhang & Cheng Zhang, 2013. "Impact of Angiotensin I Converting Enzyme Insertion/Deletion Polymorphisms on Dilated Cardiomyopathy and Hypertrophic Cardiomyopathy Risk," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-6, May.
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