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Effect of pueraria on left ventricular remodelling in HFrEF: A systematic review and meta-analysis

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  • Lipeng Shi
  • Lumei Huang
  • Erqian Yin
  • Jingwei Deng
  • Xuqin Du

Abstract

Background: Heart failure with reduced ejection fraction (HFrEF) is a prevalent cardiovascular disease globally, posing a significant burden on healthcare and society. Left ventricular remodelling is the primary pathology responsible for HFrEF development and progression, leading to increased morbidity and mortality. Pueraria, a traditional Chinese herbal medicine and food, is commonly used in China to treat HFrEF. Accumulating evidence suggests that pueraria can effectively reverse left ventricular remodelling in HFrEF patients. This meta-analysis aims to assess the impact of pueraria on left ventricular remodelling in HFrEF patients. Methods: Eight electronic databases, including PubMed, EMBASE, Clinicaltrials.gov, Cochrane Library, Wanfang, CNKI, CQVIP, and CBM were searched for literature from inception to June 2023. All randomized controlled trials (RCTs) using pueraria in the treatment of HFrEF were included. The Cochrane Risk of Bias tool was utilized for RCTs’ methodological evaluation, while Review Manager 5.4.1 was used to analyze the data. Results: Nineteen RCTs with a total of 1,911 patients (1,077 males and 834 females) were identified. Meta-analysis indicated that combination medication of pueraria and conventional medicine (CM) was superior to the CM alone in raising left ventricular ejection fraction (LVEF; MD = 6.46, 95% CI, 4.88 to 8.04, P

Suggested Citation

  • Lipeng Shi & Lumei Huang & Erqian Yin & Jingwei Deng & Xuqin Du, 2023. "Effect of pueraria on left ventricular remodelling in HFrEF: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 18(12), pages 1-16, December.
    • Handle: RePEc:plo:pone00:0295344
    DOI: 10.1371/journal.pone.0295344
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