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Recombinant human adenovirus p53 combined with transcatheter arterial chemoembolization for liver cancer: A meta-analysis

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Listed:
  • Yaru Guo
  • Yuanyuan Chen
  • Yingnan Zhang
  • Mengjun Xu
  • Wenwen Guo
  • Jingya Zhang
  • Gaolei Ma
  • Chen Liu
  • Juan Yang
  • Xiaojin Wu

Abstract

Objectives: To compare the clinical curative effects, survival and complications of recombinant human adenovirus-p53 (rAd-p53) combined with transcatheter arterial chemoembolization (TACE) versus TACE for the treatment of liver cancer. Methods: We searched all the eligible studies of rAd-p53 plus TACE versus control group had only TACE in the treatment of liver cancer, which were retrieved from CNKI, Wanfang database, CBM, VIP, PubMed, EMBase, The Chrance of Library, Web of Science from its inception to august 2022. Results: A total of 17 studies were included, which involved 1045 patients. The results of the meta analysis indicated that the the rAd-p53combined with TACE markedly improved the patients’ complete remission(OR = 2.19, 95% CI:1.13–4.22, P = 0.02), partial remission (OR = 2.22, 95% CI:1.67–2.94, P

Suggested Citation

  • Yaru Guo & Yuanyuan Chen & Yingnan Zhang & Mengjun Xu & Wenwen Guo & Jingya Zhang & Gaolei Ma & Chen Liu & Juan Yang & Xiaojin Wu, 2023. "Recombinant human adenovirus p53 combined with transcatheter arterial chemoembolization for liver cancer: A meta-analysis," PLOS ONE, Public Library of Science, vol. 18(12), pages 1-23, December.
    • Handle: RePEc:plo:pone00:0295323
    DOI: 10.1371/journal.pone.0295323
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