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Age-associated mortality is partially mediated by TERT promoter mutation status in differentiated thyroid carcinoma

Author

Listed:
  • Jung Heo
  • Sungjoo Lee
  • Jun Park
  • Heera Yang
  • Hyunju Park
  • Chang-Seok Ki
  • Young Lyun Oh
  • Hye In Kim
  • Sun Wook Kim
  • Jae Hoon Chung
  • Kyunga Kim
  • Tae Hyuk Kim

Abstract

Background: Age at diagnosis (AAD) and telomerase reverse transcriptase (TERT) promoter mutations are prognostic factors in differentiated thyroid carcinoma (DTC), and the prevalence of the mutations increases with AAD. Considering this correlation, we investigated whether an interaction between AAD and the mutations is present and whether the mutation mediates the effect of AAD on the mortality rate in DTC. Methods: The study included 393 patients with DTC who were followed-up after thyroidectomy at a single medical center in Korea from 1994 to 2004. Multivariable Cox regression was used to investigate the interaction of AAD and TERT promoter mutation. Mediation analysis was conducted using a regression-based causal mediation model. Results: The age-associated mortality rate increased progressively in all DTC patients and wild-type TERT group (WT-TERT) with a linear trend (p

Suggested Citation

  • Jung Heo & Sungjoo Lee & Jun Park & Heera Yang & Hyunju Park & Chang-Seok Ki & Young Lyun Oh & Hye In Kim & Sun Wook Kim & Jae Hoon Chung & Kyunga Kim & Tae Hyuk Kim, 2023. "Age-associated mortality is partially mediated by TERT promoter mutation status in differentiated thyroid carcinoma," PLOS ONE, Public Library of Science, vol. 18(11), pages 1-16, November.
    • Handle: RePEc:plo:pone00:0294145
    DOI: 10.1371/journal.pone.0294145
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