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The association between polypharmacy and health-related quality of life among non-dialysis chronic kidney disease patients

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  • Leonie Adjeroh
  • Todd Brothers
  • Khaled Shawwa
  • Mohammad Ikram
  • Mohammad A Al-Mamun

Abstract

Background and objective: The United States government spends over $85 billion annually on treating non-dialysis chronic kidney disease (CKD). Patients with CKD are prescribed a multitude of medications to manage numerous comorbidities associated with CKD. Thus, this study aims to investigate the association between polypharmacy and health-related quality of life (HRQoL) in non-dialysis CKD patients. Methods: This cross-sectional study utilized data from the Medical Expenditure Panel Survey (MEPS) from 2010 through 2019. We classified polypharmacy into three groups based on the number of medication classes: ≤ 4 (minor polypharmacy), 5 through 9 (major polypharmacy), and ≥ 10 (hyperpolypharmacy). To measure HRQoL, a Physical Component Summary (PCS) and a Mental Component Summary (MCS) were obtained from the 12-item Short-Form Health Survey version 2 and Veteran’s Rand 12 item. We applied multivariable ordinary least squares regression to assess the association between polypharmacy and HRQoL in non-dialysis CKD patients. Results: A total of 649 CKD patients (weighted n = 667,989) were included. Patients with minor polypharmacy, major polypharmacy, and hyperpolypharmacy were 22.27%, 48.24%, and 29.48%, respectively. Major polypharmacy and hyperpolypharmacy were significantly and negatively associated with lower PCS scores when compared with minor polypharmacy [Beta = -3.12 (95% CI: -3.62, -2.62), p-value

Suggested Citation

  • Leonie Adjeroh & Todd Brothers & Khaled Shawwa & Mohammad Ikram & Mohammad A Al-Mamun, 2023. "The association between polypharmacy and health-related quality of life among non-dialysis chronic kidney disease patients," PLOS ONE, Public Library of Science, vol. 18(11), pages 1-19, November.
    • Handle: RePEc:plo:pone00:0293912
    DOI: 10.1371/journal.pone.0293912
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    References listed on IDEAS

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    1. Wubshet H. Tesfaye & Charlotte McKercher & Gregory M. Peterson & Ronald L. Castelino & Matthew Jose & Syed Tabish R. Zaidi & Barbara C. Wimmer, 2020. "Medication Adherence, Burden and Health-Related Quality of Life in Adults with Predialysis Chronic Kidney Disease: A Prospective Cohort Study," IJERPH, MDPI, vol. 17(1), pages 1-13, January.
    2. Benjamin R Fletcher & Sarah Damery & Olalekan Lee Aiyegbusi & Nicola Anderson & Melanie Calvert & Paul Cockwell & James Ferguson & Mike Horton & Muirne C S Paap & Chris Sidey-Gibbons & Anita Slade & N, 2022. "Symptom burden and health-related quality of life in chronic kidney disease: A global systematic review and meta-analysis," PLOS Medicine, Public Library of Science, vol. 19(4), pages 1-25, April.
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