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Sleep disorders and risk of infertility: A meta-analysis of observational studies

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  • Xiaoxiao Qin
  • Siyun Fang
  • Yaqi Cai

Abstract

Objective: The purpose of this study was to determine the relationship between sleep disorders and risk of infertility. Method: Three databases (PubMed, Embase, and Cochrane Library) were searched form their inception to April 30, 2023. Information of study design, control group and experimental group, number of participants, and study outcomes was extracted. The quality of the studies was evaluated using the Newcastle-Ottawa Scale (NOS scale) and the Agency for Healthcare Research and Quality (AHRQ scale). Narrative synthesis and meta-analysis were used to analyze these studies. Result: Eight cohort, cross-sectional, and case-control studies were considered. The reviewed studies were high-quality. Pooled analysis showed that the risk of infertility was 1.43-fold higher in patients with sleep disturbance (HR = 1.43, 95% CI, 0.97–2.11, z = 1.79), but this was not statistically different; the risk was 1.58-fold higher in patients with OSA compared to those without OSA (HR = 1.58, 95%, CI, 0.99–2.52, z = 1.91), but this was not statistically significant. Wake-up time is also associated with infertility (OR = 1.14; 95%CI = 1.01–1.28; P = 0.037). For every hour they stay awake beyond 8:00 AM, participants had a 41% higher risk of infertility (P = 0.004). The early-to-bed/late-to-rise (EL), LE, and LL groups had a higher risk of infertility than the EE group. Conclusion: The present study did not find an association between sleep disorders and the risk of infertility. Therefore, more observational studies are warranted to explore the association between sleep disorders and the risk of infertility.

Suggested Citation

  • Xiaoxiao Qin & Siyun Fang & Yaqi Cai, 2023. "Sleep disorders and risk of infertility: A meta-analysis of observational studies," PLOS ONE, Public Library of Science, vol. 18(10), pages 1-10, October.
    • Handle: RePEc:plo:pone00:0293559
    DOI: 10.1371/journal.pone.0293559
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    1. Zhu Wei Lim & I-Duo Wang & Panchalli Wang & Chi-Hsiang Chung & Song-Shan Huang & Chien-Chu Huang & Pei-Yi Tsai & Gwo-Jang Wu & Kuo-Hsiang Wu & Wu-Chien Chien, 2021. "Obstructive sleep apnea increases risk of female infertility: A 14-year nationwide population-based study," PLOS ONE, Public Library of Science, vol. 16(12), pages 1-12, December.
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