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Periodontal disease and visfatin level: A systematic review and meta-analysis

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  • Mojtaba Bayani
  • MohammadTaha Heidari
  • Amir Almasi-Hashiani

Abstract

Visfatin is considered an inflammatory biomarker in periodontal disease (PD). In this meta-analysis, we aimed to evaluate the relationship between Visfatin biomarker level with PD. In this study, Medline, Scopus, Web of Science, and Google Scholar were searched. We included studies that examined visfatin levels in samples from healthy people and periodontal disease until March 2023. The quality of the selected articles was evaluated using the Newcastle-Ottawa assessment scale. Depending on heterogeneity of studies, random-effects or fixed-effect models were used to pool results and report the standardized mean difference (SMD). After screening the retrieved papers, the related data were extracted. A total of 159 studies were identified, and 16 studies were included in the meta-analysis. In 9 studies, the SMD of visfatin level of gingival crevicular fluid (GCF) in patients with chronic periodontitis (CP) and healthy individuals was 4.32 (p

Suggested Citation

  • Mojtaba Bayani & MohammadTaha Heidari & Amir Almasi-Hashiani, 2023. "Periodontal disease and visfatin level: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 18(11), pages 1-19, November.
    • Handle: RePEc:plo:pone00:0293368
    DOI: 10.1371/journal.pone.0293368
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