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Atopic dermatitis and cognitive dysfunction in middle-aged and older adults: A systematic review and meta-analysis

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  • Qi Zhou
  • Dejiang Yang
  • Chongyu Xiong
  • Xinming Li

Abstract

Background: Atopic dermatitis (AD) is a common chronic inflammatory skin disease that affects adults worldwide. Recent evidence suggests that AD may be associated with cognitive dysfunction, but the results of individual studies have been inconsistent. This systematic review and meta-analysis aimed to evaluate the association between AD and cognitive dysfunction in middle-aged and older adults. Methods: To find relevant research, a comprehensive search of electronic databases from the beginning to March 2023 was carried out. Data were taken from studies that were eligible, and a meta-analysis was done to determine the pooled hazard ratio (HR) and 95% confidence interval (CI). Results: We searched three databases and found a total of 15 studied arms included in 5 cohort studies with over 8.5 million participants were included in the analysis. The results showed that individuals with AD had a higher risk of developing dementia of all-cause dementia (pooled hazard ratio (HR) = 1.16; 95% CI, 1.10–1.23,P

Suggested Citation

  • Qi Zhou & Dejiang Yang & Chongyu Xiong & Xinming Li, 2023. "Atopic dermatitis and cognitive dysfunction in middle-aged and older adults: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 18(10), pages 1-10, October.
    • Handle: RePEc:plo:pone00:0292987
    DOI: 10.1371/journal.pone.0292987
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