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Effects of the pre-existing coronary heart disease on the prognosis of COVID-19 patients: A systematic review and meta-analysis

Author

Listed:
  • Saikun Wang
  • Ruiting Zhu
  • Chengwei Zhang
  • Yingze Guo
  • Mengjiao Lv
  • Changyue Zhang
  • Ce Bian
  • Ruixue Jiang
  • Wei Zhou
  • Lirong Guo

Abstract

Although studies have shown severe Coronavirus disease 2019 (COVID-19) outcomes in patients with pre-existing coronary heart disease (CHD), the prognosis of COVID-19 patients with pre-existing CHD remains uncertain primarily due to the limited number of patients in existing studies. This study aimed to investigate the impacts of pre-existing CHD on the prognosis of COVID-19 patients. Five electronic databases were searched for eligible studies. This article focused on cohort and case-control studies involving the prognosis of COVID-19 patients with pre-existing CHD. The meta-analysis was performed using a random effects model. The odds ratios (ORs) and 95% confidence intervals (CIs) were used as valid indicators. The study was registered in PROSPERO with the identifier: CRD42022352853. A total of 81 studies, involving 157,439 COVID-19 patients, were included. The results showed that COVID-19 patients with pre-existing CHD exhibited an elevated risk of mortality (OR = 2.45; 95%CI: [2.04, 2.94], P

Suggested Citation

  • Saikun Wang & Ruiting Zhu & Chengwei Zhang & Yingze Guo & Mengjiao Lv & Changyue Zhang & Ce Bian & Ruixue Jiang & Wei Zhou & Lirong Guo, 2023. "Effects of the pre-existing coronary heart disease on the prognosis of COVID-19 patients: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 18(10), pages 1-22, October.
  • Handle: RePEc:plo:pone00:0292021
    DOI: 10.1371/journal.pone.0292021
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