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Causal relationship between body mass index, type 2 diabetes and bone mineral density: Mendelian randomization

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  • Weiwei Ma
  • Xiaohong Zhou
  • Xin Huang
  • Yong Xiong

Abstract

Objective: To reveal the relationship between Body Mass Index(BMI), type 2 diabetes, and bone mineral density(BMD) using a mendelian randomization (MR) approach. Methods: GWAS data on BMI, type 2 diabetes, and BMD were selected from the IEU GWAS database at the University of Bristol.Univariable, multivariable, and mediated MR analyses were used to explore the relationship between BMI, type 2 diabetes, and BMD. beta(β) values were given, and three methods, including inverse variance weighting, MR-Egger regression, and weighted median, were used in this analysis. Results: Univariable mendelian randomization (UVMR) results showed that BMI and type 2 diabetes were positively associated with BMD. However, the association between BMI and BMD was insignificant in the multivariable Mendelian randomization (MVMR) analysis, while that between type 2 diabetes and BMD remained significant. Mediated MR analysis indicated that type 2 diabetes mediated the regulation of BMD by BMI. Conclusion: This study provides evidence supporting a positive causal association between BMI, type 2 diabetes, and BMD. Type 2 diabetes acts as a mediator in the regulation of BMD by BMI, indicating that both BMI and type 2 diabetes exert a protective influence on BMD.

Suggested Citation

  • Weiwei Ma & Xiaohong Zhou & Xin Huang & Yong Xiong, 2023. "Causal relationship between body mass index, type 2 diabetes and bone mineral density: Mendelian randomization," PLOS ONE, Public Library of Science, vol. 18(10), pages 1-13, October.
    • Handle: RePEc:plo:pone00:0290530
    DOI: 10.1371/journal.pone.0290530
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    1. Angli Xue & Yang Wu & Zhihong Zhu & Futao Zhang & Kathryn E. Kemper & Zhili Zheng & Loic Yengo & Luke R. Lloyd-Jones & Julia Sidorenko & Yeda Wu & Allan F. McRae & Peter M. Visscher & Jian Zeng & Jian, 2018. "Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
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    1. Yuxiang Wu & Weiwei Ma & Zhenda Cheng & Qiwei Zhang & Zhaodong Li & Punan Weng & Bushuang Li & Zhiqiang Huang & Changlong Fu, 2024. "Causal relationships between body mass index, low-density lipoprotein and bone mineral density: Univariable and multivariable Mendelian randomization," PLOS ONE, Public Library of Science, vol. 19(6), pages 1-14, June.

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