IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0290003.html
   My bibliography  Save this article

S-1 and 5-Fluorouracil-related adverse events in patients with advanced gastric cancer: A meta-analysis

Author

Listed:
  • Qingqing Hu
  • Jiajia Xu
  • Jingshu Ke
  • Ziye Zhang
  • Ting Chu

Abstract

Objective: To assess S-1 and 5-fluorouracil (5-FU)-related adverse events in patients with advanced gastric cancer and provide focused health care approaches to improve patient compliance and quality of survival. Methods: The PubMed, Web of Science, Medline, Cochrane Library, EMbase, SinoMed, Wan Fang Data, CNKI, and VIP databases were searched, and relevant literature was screened from the database construction date through March 31, 2023. Review Manager 5.4.1 and Stata 12.0 were used to analyze the data and GRADEpro was used to assess the quality of the literature. Relative risk ratio (RR) and a 95% confidence interval (CI) were employed as markers to compare adverse events due to S-1 vs 5-FU. Results: Eight randomized controlled trials (RCT) were included, which contained 3,455 patients. The S-1 group had 1,804 patients, and the 5-FU group had 1,651 patients. There were 17 recorded adverse events in total. Stomatitis, hypokalemia, mucosal inflammation, and hypophosphatemia were more common in the 5-FU group than in the S-1 group (P

Suggested Citation

  • Qingqing Hu & Jiajia Xu & Jingshu Ke & Ziye Zhang & Ting Chu, 2023. "S-1 and 5-Fluorouracil-related adverse events in patients with advanced gastric cancer: A meta-analysis," PLOS ONE, Public Library of Science, vol. 18(8), pages 1-16, August.
    • Handle: RePEc:plo:pone00:0290003
    DOI: 10.1371/journal.pone.0290003
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0290003
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0290003&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0290003?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Ming-ming He & Wen-jing Wu & Feng Wang & Zhi-qiang Wang & Dong-sheng Zhang & Hui-yan Luo & Miao-zhen Qiu & Feng-hua Wang & Chao Ren & Zhao-lei Zeng & Rui-hua Xu, 2013. "S-1-Based Chemotherapy versus Capecitabine-Based Chemotherapy as First-Line Treatment for Advanced Gastric Carcinoma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-1, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      More about this item

      Statistics

      Access and download statistics

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0290003. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.