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Correlation of a commercial platform’s results with post-vaccination SARS-CoV-2 neutralizing antibody response and clinical host factors

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  • Rebecca Slotkin
  • Tassos C Kyriakides
  • Anupam Kundu
  • Gary Stack
  • Richard E Sutton
  • Shaili Gupta

Abstract

Introduction: The objective of this study was to describe the correlation between the commercially available assay for anti-S1/RBD IgG and protective serum neutralizing antibodies (nAb) against SARS-CoV-2 in an adult population after SARS-CoV-2 vaccination, and determine if clinical variables impact this correlation. Methods: We measured IgG anti-S1/RBD using the IgG-II CMIA assay and nAb IC50 values against SARS-CoV-2 WA-1 in sera serially collected post-mRNA vaccination in veterans and healthcare workers of the Veterans Affairs Connecticut Healthcare System (VACHS) between December 2020 and January 2022. The correlation between IgG and IC50 was measured using Pearson correlation. Clinical variables (age, sex, race, ethnicity, prior COVID infection defined by RT-PCR, history of malignancy, estimated glomerular filtration rate (GFR calculated using CKD-EPI equation) were collected by manual chart review. The impact of these clinical variables on the IgG-nAb correlation was analyzed first with univariable regression. Variables with a significance of p

Suggested Citation

  • Rebecca Slotkin & Tassos C Kyriakides & Anupam Kundu & Gary Stack & Richard E Sutton & Shaili Gupta, 2023. "Correlation of a commercial platform’s results with post-vaccination SARS-CoV-2 neutralizing antibody response and clinical host factors," PLOS ONE, Public Library of Science, vol. 18(8), pages 1-7, August.
    • Handle: RePEc:plo:pone00:0289713
    DOI: 10.1371/journal.pone.0289713
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