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Efficacy and safety of acupuncture for vocal nodules: A systematic review and meta-analysis with trial sequential analysis

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  • Zhixian Xiao
  • Qinwei Fu
  • Xiaocui Long
  • Li Zhou
  • Ruijing Zhu
  • Qianlin Peng
  • Xingbi Xie
  • Yiru Liao

Abstract

In this study, we aim to evaluate the efficacy and safety of acupuncture for vocal nodules, concerning qualitive overall efficacy and quantitative improvement on quality of voice. Four English and four Chinese databases were searched up to December 10th, 2022. Risk of bias among the included trials were evaluated by the Cochrane ROB tool. Systematic reviews and meta-analyses were conducted based on the Cochrane systematic review method by using RevMan 5.4 Software, and trial sequential analyses were performed by TSA 0.9. Meta-influence analyses, subgroup-analyses, meta-regression, and evaluation of publication bias were performed for exploration of heterogeneity by Stata V.14. Quality of the results was accessed through the GRADE-pro GDT. Cluster analyses and correlation coefficient were performed by R 4.1.3. Finally, 15 trials involving 1,888 participants were included. Results showed that compared with western medicine alone or Chinese herbal medicine alone, acupuncture alone yielded significantly (p

Suggested Citation

  • Zhixian Xiao & Qinwei Fu & Xiaocui Long & Li Zhou & Ruijing Zhu & Qianlin Peng & Xingbi Xie & Yiru Liao, 2023. "Efficacy and safety of acupuncture for vocal nodules: A systematic review and meta-analysis with trial sequential analysis," PLOS ONE, Public Library of Science, vol. 18(11), pages 1-17, November.
    • Handle: RePEc:plo:pone00:0288252
    DOI: 10.1371/journal.pone.0288252
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    References listed on IDEAS

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    1. Wei Zhang & Liyan Ma & Brent A Bauer & Zhishun Liu & Yao Lu, 2017. "Acupuncture for benign prostatic hyperplasia: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-15, April.
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