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The effect of adjuvant radiotherapy after breast-conserving surgery in elderly women with T1-2N0 estrogen receptor-negative breast cancer

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  • Can Chen
  • Runlu Wang
  • Bing Wang
  • Yue Wu
  • Jingting Jiang

Abstract

Purpose: To evaluate whether adjuvant radiotherapy (RT) following breast-conserving surgery (BCS) results in better survival among women ≥ 70 years with T1-2N0 estrogen receptor (ER)-negative breast cancer. Methods: In this retrospective cohort study, we included patients who met the inclusion criteria between 2010 and 2015 from the Surveillance, Epidemiology, and End Results (SEER) program. Univariate and Multivariate Cox proportional analysis were used to identify the risk factors for overall survival (OS) and breast cancer-specific survival (BCSS). Kaplan-Meier survival analysis was used to compare the prognosis of patients with or without adjuvant RT. Propensity score matching (PSM) was applied to perform a 1:1 matched case-control analysis. Results: A total of 4201 women were included in this study, with a median follow-up time of 64 months (range: 0–107 months). Of these patients, 2811 (66.9%) received adjuvant RT, while 1390 (33.1%) did not. Patients who did not receive adjuvant RT were more likely to be aged ≥ 80 years old, have a single marital status, larger tumors, and HER2-positive status (p

Suggested Citation

  • Can Chen & Runlu Wang & Bing Wang & Yue Wu & Jingting Jiang, 2023. "The effect of adjuvant radiotherapy after breast-conserving surgery in elderly women with T1-2N0 estrogen receptor-negative breast cancer," PLOS ONE, Public Library of Science, vol. 18(8), pages 1-13, August.
    • Handle: RePEc:plo:pone00:0288078
    DOI: 10.1371/journal.pone.0288078
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