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Homocysteine levels in patients with coronary slow flow phenomenon: A meta-analysis

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  • Hong Yu
  • Bei-Bei Wang
  • Meng Zhao
  • Feng Feng
  • Hua-Dong Li

Abstract

Background: With the development of coronary angiography, more and more attention has been paid to coronary slow flow phenomenon (CSFP). Recent studies have found that the correlation between homocysteine (Hcy) levels and CSFP was contradictory, so we conducted this meta-analysis to investigate the correlation. Methods: By March 2022, studies that meet the research requirements were identified by searching multiple databases including Embase, Web of Science, and PubMed. We included studies evaluating the correlation between Hcy levels and CSFP. Random or fixed effect meta-analyses were performed according to heterogeneity among included studies. A leave-out method and subgroup analyses were conducted to determine the source of heterogeneity. Results: Thirteen studies involving 625 CSFP and 550 subjects were included. After pooling data from each study, Hcy levels were higher in the CSFP groups (standard mean difference [SMD], 1.45; 95% CI, 0.94 to 1.96, P

Suggested Citation

  • Hong Yu & Bei-Bei Wang & Meng Zhao & Feng Feng & Hua-Dong Li, 2023. "Homocysteine levels in patients with coronary slow flow phenomenon: A meta-analysis," PLOS ONE, Public Library of Science, vol. 18(7), pages 1-11, July.
    • Handle: RePEc:plo:pone00:0288036
    DOI: 10.1371/journal.pone.0288036
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