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Efficacy and safety of patients with chronic kidney disease undergoing left atrial appendage closure for atrial fibrillation

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  • Chaofan Liu
  • Shaojie Han
  • Kaijun Cui
  • Fang Wang

Abstract

Background: The relative safety and efficacy of left atrial appendage closure (LAAC) for atrial fibrillation (AF) in patients with chronic kidney disease (CKD) have not been well defined. To evaluate the results in this cohort, we conducted a systematic review and meta-analysis of observational studies. Methods: We searched the PubMed, EMBASE, Web of Science, and Cochrane Library databases from inception to January 2023 for all relevant studies. Our inclusion criteria were met by twelve observational studies that included 61324 patients altogether. Results: Compared with no CKD group, in-hospital mortality (OR: 2.84, 95% CI: 2.12–3.81, p

Suggested Citation

  • Chaofan Liu & Shaojie Han & Kaijun Cui & Fang Wang, 2023. "Efficacy and safety of patients with chronic kidney disease undergoing left atrial appendage closure for atrial fibrillation," PLOS ONE, Public Library of Science, vol. 18(10), pages 1-15, October.
  • Handle: RePEc:plo:pone00:0287928
    DOI: 10.1371/journal.pone.0287928
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