IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0287463.html
   My bibliography  Save this article

Prospective outcome analysis of multiple sclerosis cases reveals candidate prognostic cerebrospinal fluid markers

Author

Listed:
  • Elif Everest
  • Ugur Uygunoglu
  • Melih Tutuncu
  • Alper Bulbul
  • Umut Inci Onat
  • Mehmetcan Unal
  • Timucin Avsar
  • Sabahattin Saip
  • Ugur Bilge
  • Eda Tahir Turanli
  • Aksel Siva

Abstract

Background: Predicting the long-term disability outcomes of multiple sclerosis (MS) cases is challenging. Objective: We prospectively analysed our previous MS cohort with initial cerebrospinal fluid (CSF) proteomics data to reveal disability markers after 8.2±2.2 years of follow-up. Methods: Patients with regular follow-up visits were assigned into two groups: those with an age-related MS severity (ARMSS) score ≥5 (unfavourable course group, N = 27) and ARMSS score 9 lesions) on magnetic resonance imaging, gait disturbance (P = 0.04), and bladder/bowel symptoms (P = 0.01) were significantly higher in the unfavourable course group than in the favourable course group. Optic nerve involvement evident on initial magnetic resonance imaging (P = 0.002) and optic neuritis (P = 0.01) were more frequent in the favourable course group. Conclusion: The herein identified initial CSF protein levels, in addition to the clinical and radiological parameters at disease onset, have predictive value for long-term disability in MS cases.

Suggested Citation

  • Elif Everest & Ugur Uygunoglu & Melih Tutuncu & Alper Bulbul & Umut Inci Onat & Mehmetcan Unal & Timucin Avsar & Sabahattin Saip & Ugur Bilge & Eda Tahir Turanli & Aksel Siva, 2023. "Prospective outcome analysis of multiple sclerosis cases reveals candidate prognostic cerebrospinal fluid markers," PLOS ONE, Public Library of Science, vol. 18(6), pages 1-11, June.
    • Handle: RePEc:plo:pone00:0287463
    DOI: 10.1371/journal.pone.0287463
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0287463
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0287463&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0287463?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0287463. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.