IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0287122.html
   My bibliography  Save this article

Analysis of clozapine-induced seizures using the Japanese Adverse Drug Event Report database

Author

Listed:
  • Masakazu Hatano
  • Kaho Yamada
  • Haruna Matsuzaki
  • Rina Yokoi
  • Takeo Saito
  • Shigeki Yamada

Abstract

Among antipsychotics, clozapine is associated with a high risk of seizures. This study aimed to generate novel hypotheses regarding trends in the onset of clozapine-induced seizures using the JADER (Japanese Adverse Drug Event Report) database. Seizures were defined according to the Standardized MedDRA Queries (SMQ) for convulsions (SMQ20000079). Trends in the onset of clozapine-induced seizures were assessed using multivariate logistic regression analysis with covariates of sex, age, clozapine dose, antipsychotic polypharmacy, concomitant medications, and history of convulsive disorder. In addition, we assessed the time-to-onset of clozapine-induced seizures using the median time, interquartile range, and Weibull shape parameter. The JADER database registered 2,745 cases of adverse events with clozapine, and 1,784 cases were included in the analysis after excluding cases for which clinical information was not available. Medium (200–400 mg) and high (> 400 mg) doses of clozapine had a significantly higher reporting rate of seizures than low doses (

Suggested Citation

  • Masakazu Hatano & Kaho Yamada & Haruna Matsuzaki & Rina Yokoi & Takeo Saito & Shigeki Yamada, 2023. "Analysis of clozapine-induced seizures using the Japanese Adverse Drug Event Report database," PLOS ONE, Public Library of Science, vol. 18(6), pages 1-10, June.
    • Handle: RePEc:plo:pone00:0287122
    DOI: 10.1371/journal.pone.0287122
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0287122
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0287122&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0287122?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0287122. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.