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Efficacy of nitrous oxide in adults undergoing puncture biopsy: A systematic review and meta-analysis of randomized controlled trials

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  • Ziyang Wang
  • Fei Wang
  • Yihui Xing
  • Xiaochen Jiang
  • Zhiguo Ding
  • Yuxiang Li
  • Lu Tang

Abstract

Background: Nitrous oxide (N2O) with rapid analgesic effect is often used to relieve pain induced by diagnostic procedures. This review was conducted to evaluate the efficacy and safety of N2O in patients undergoing puncture biopsy. Methods: We systematically searched PubMed, Embase, the Cochrane Library, Web of Science, Scopus and the ClinicalTrials.gov up to March, 2022. Randomized controlled trials (RCTs) were included if they investigated the effect of N2O in adults undergoing puncture biopsy. The primary outcome was pain score. Secondary outcomes included anxiety score, patient satisfaction and side effects. Results: Twelve RCTs with 1070 patients were included in the qualitative review, of which eleven RCTs were included in the meta-analysis. Pooled analysis suggested that compared with the controls (placebo, lidocaine and midazolam), N2O had better analgesic effect (MD -1.12, 95% CI -2.12 to -0.13, P = 0.03; I2 = 94%). In addition, N2O significantly alleviated patient anxiety (MD = -1.79, 95% CI -2.41 to -1.18, P

Suggested Citation

  • Ziyang Wang & Fei Wang & Yihui Xing & Xiaochen Jiang & Zhiguo Ding & Yuxiang Li & Lu Tang, 2023. "Efficacy of nitrous oxide in adults undergoing puncture biopsy: A systematic review and meta-analysis of randomized controlled trials," PLOS ONE, Public Library of Science, vol. 18(6), pages 1-15, June.
    • Handle: RePEc:plo:pone00:0286713
    DOI: 10.1371/journal.pone.0286713
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    References listed on IDEAS

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    1. Amy E. Moore & Rebecca L. Trotta & Steven C. Palmer & Regina S. Cunningham & Rosemary C. Polomano, 2020. "A Multivariate Analysis of Pain and Distress in Adults Undergoing BMAB," Clinical Nursing Research, , vol. 29(8), pages 530-542, November.
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    Cited by:

    1. Xueling Qiu & Lukun Sun & Lu Tang & Xiaochen Jiang & Weifeng Wang & Fan Sun & Chenxi Sun & Tianyi Song, 2024. "The efficacy of virtual reality in adults during puncture biopsy: A protocol of a systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 19(12), pages 1-10, December.

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