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Diagnostic accuracy of the Copenhagen Index in ovarian malignancy: A meta-analysis

Author

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  • Huiling Liu
  • Shouye Ma
  • Xiaohong Chen
  • Huifang Wu
  • Rongrong Wang
  • Mengmeng Du
  • Xiazi Nie

Abstract

Objective: To assess the diagnostic value of the Copenhagen index for ovarian malignancy. Methods: PubMed, Web of Science, the Cochrane Library, Embase, CBM, CNKI, and WanFang databases were searched throughout June 2021. Statistical analyses were performed using Stata 12, Meta-DiSc, and RevMan 5.3. The pooled sensitivity, specificity, and diagnostic odds ratio were calculated, the summary receiver operating characteristic curve was drawn, and the area under the curve was calculated. Results: Ten articles, including 11 studies with a total of 5266 patients, were included. The pooled sensitivity, specificity, and diagnostic odds ratio were 0.82 [95% CI (0.80–0.83)], 0.88 [95% CI (0.87–0.89)], and 57.31 [95% CI (32.84–100.02)], respectively. The area under the summary receiver operating characteristics curve and the Q index were 0.9545 and 0.8966, respectively. Conclusion: Our systematic review shows that the sensitivity and specificity of the Copenhagen index are high enough for it to be used in a clinical setting to provide accurate ovarian cancer diagnosis without considering menopausal status.

Suggested Citation

  • Huiling Liu & Shouye Ma & Xiaohong Chen & Huifang Wu & Rongrong Wang & Mengmeng Du & Xiazi Nie, 2023. "Diagnostic accuracy of the Copenhagen Index in ovarian malignancy: A meta-analysis," PLOS ONE, Public Library of Science, vol. 18(6), pages 1-11, June.
    • Handle: RePEc:plo:pone00:0286650
    DOI: 10.1371/journal.pone.0286650
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