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Exploring biomarkers and prognostic factors in uterine carcinosarcoma: An insight into L1CAM, CDX2, p53, and MSI status

Author

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  • Jesse Lopes da Silva
  • Lucas Zanetti de Albuquerque
  • Fabiana Resende Rodrigues
  • Nina Carrossini Bastos
  • Isabele Avila Small
  • Elisa Bouret Campos Barroso
  • Fernando Lopes Cordero
  • Daniel de Souza Fernandes
  • Eduardo Paulino
  • Andreia Cristina de Melo

Abstract

Background: Uterine Carcinosarcomas (UCS) are a rare type of cancer composed of an admixture of high-grade carcinomatous and sarcomatous elements. Clinicopathological prognostic factors in UCS are well established, but studies that approach the impact of biomarkers in this unusual disease are scarce. The study objective was to evaluate the prevalence and prognostic impact of a panel of prominent biomarkers in uterine carcinosarcoma (UCS) using an immunohistochemical characterization with four biomarkers. Methods and findings: The internal database of a single Brazilian institution was carefully explored to select women diagnosed with UCS who were submitted to surgery and postoperative chemotherapy with carboplatin and paclitaxel between January 2012 and December 2017. Tissue microarrays containing UCS samples were evaluated by immunohistochemistry for L1CAM, CDX2, p53 and microsatellite instability markers. A total of 57 cases were included. The mean age was 65.3 years (standard deviation, SD 7.0). L1CAM was negative (score 0, no staining) in 27 (47.4%) patients. Of L1CAM-positive, 10 (17.5%) showed weak (score 1,

Suggested Citation

  • Jesse Lopes da Silva & Lucas Zanetti de Albuquerque & Fabiana Resende Rodrigues & Nina Carrossini Bastos & Isabele Avila Small & Elisa Bouret Campos Barroso & Fernando Lopes Cordero & Daniel de Souza , 2023. "Exploring biomarkers and prognostic factors in uterine carcinosarcoma: An insight into L1CAM, CDX2, p53, and MSI status," PLOS ONE, Public Library of Science, vol. 18(5), pages 1-15, May.
    • Handle: RePEc:plo:pone00:0285447
    DOI: 10.1371/journal.pone.0285447
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    1. Osamu Gotoh & Yuko Sugiyama & Yutaka Takazawa & Kazuyoshi Kato & Norio Tanaka & Kohei Omatsu & Nobuhiro Takeshima & Hidetaka Nomura & Kosei Hasegawa & Keiichi Fujiwara & Mana Taki & Noriomi Matsumura , 2019. "Clinically relevant molecular subtypes and genomic alteration-independent differentiation in gynecologic carcinosarcoma," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
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