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Efficacy and safety of Weifuchun tablet for chronic atrophic gastritis: A systematic review and meta-analysis

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  • Longhua Wang
  • Xia Ding
  • Ping Li
  • Fuwen Zhang
  • Shuying Ru
  • Fenglei Wang
  • Lan Li

Abstract

Background: Chronic atrophic gastritis is a significant premalignant lesion of gastric carcinoma. There is a great need to prevent the progression to gastric carcinoma through early intervention and treatment for chronic atrophic gastritis. Weifuchun, a famous Chinese patent drug, has been widely used for chronic atrophic gastritis in China. However, it remains unclear whether Weifuchun is effective for atrophic gastritis. Objective: To determine the effectiveness and safety of Weifuchun for chronic atrophic gastritis. Methods: We systematically retrieved seven databases (Cochrane Library, EMBASE, PubMed, China National Knowledge Infrastructure, Wanfang database, Chinese Scientific Journals Database, and Chinese Biological Medical Database) from their inception to October 5, 2022. Methodological quality was examined using the Cochrane Risk of bias tool. We also used RevMan 5.4 software for statistical analysis to examine the effectiveness and safety of Weifuchun. Results: Fifteen studies with 1,488 patients were enrolled in this meta-analysis. The study indicated that Weifuchun was more effective (RR 1.52; 95% CI 1.41, 1.63; p

Suggested Citation

  • Longhua Wang & Xia Ding & Ping Li & Fuwen Zhang & Shuying Ru & Fenglei Wang & Lan Li, 2023. "Efficacy and safety of Weifuchun tablet for chronic atrophic gastritis: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 18(4), pages 1-15, April.
    • Handle: RePEc:plo:pone00:0284411
    DOI: 10.1371/journal.pone.0284411
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