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Ginseng-containing traditional medicine preparations in combination with fluoropyrimidine-based chemotherapy for advanced gastric cancer: A systematic review and meta-analysis

Author

Listed:
  • Jiaqi Hu
  • Mengqi Cheng
  • Yue Li
  • Bolun Shi
  • Shulin He
  • Ziang Yao
  • Juling Jiang
  • Huibo Yu
  • Zhongning He
  • Yuwei Zhao
  • Honggang Zheng
  • Baojin Hua
  • Rui Liu

Abstract

Background: Ginseng-containing traditional medicine preparations (G-TMPs) in combination with fluoropyrimidine-based chemotherapy (FBC) are well-known treatments for advanced gastric cancer (AGC), with a superior efficacy to FBC alone. However, evidence regarding their efficacy remains limited. The purpose of this meta-analysis is to evaluate the efficacy and safety of G-TMPs in combination with FBC for the treatment of AGC. Methods: Eight electronic databases were searched for randomized controlled trials (RCTs) using G-TMPs with FBC for the treatment of AGC. The primary outcome included the tumor response, while the secondary outcomes included the quality of life (QoL), proportions of peripheral blood lymphocytes, adverse drug reactions (ADRs), and levels of cancer biomarkers. The quality of evidence for each outcome was assessed using GRADE profilers. Results: A total of 1,960 participants were involved in the 26 RCTs included. Patients treated with FBC plus G-TMPs had better objective response (risk ratio [RR] = 1.23, 95% confidence interval [CI]: 1.13 to 1.35, p

Suggested Citation

  • Jiaqi Hu & Mengqi Cheng & Yue Li & Bolun Shi & Shulin He & Ziang Yao & Juling Jiang & Huibo Yu & Zhongning He & Yuwei Zhao & Honggang Zheng & Baojin Hua & Rui Liu, 2023. "Ginseng-containing traditional medicine preparations in combination with fluoropyrimidine-based chemotherapy for advanced gastric cancer: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 18(4), pages 1-34, April.
    • Handle: RePEc:plo:pone00:0284398
    DOI: 10.1371/journal.pone.0284398
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